Additional Medications for Dysautonomia & Holistic Support

The Medication Journey Continues

If you’ve been following this series, you already know that Dysautonomia isn’t a simple condition. It impacts multiple body systems, often leaving patients searching for answers. Medications can ease symptoms, but they rarely address the root causes of Dysautonomia.

In my own journey, I chose a medication-free path and eventually healed by focusing on root-cause healing. But I also know that for many, medications provide much-needed relief and stability. That’s why knowledge matters whether you rely on prescriptions, holistic therapies, or a blend of both.

In this post, we’ll look at 10 additional medications commonly prescribed for Dysautonomia, their potential benefits, side effects, and how they compare to natural support options.

10 More Dysautonomia Medications (Part 2)

11. Tricyclic Antidepressants (e.g., Doxepin)

These medications help regulate neurotransmitters, which can improve both mood and pain perception.

• Benefits: Helpful for chronic pain, sleep disturbances, and neuropathic symptoms.

• Side Effects: Drowsiness, dizziness, dry mouth, weight gain.

12. Selective Serotonin Reuptake Inhibitors (SSRIs)

Primarily used to stabilize mood and anxiety, SSRIs also influence autonomic balance.

• Benefits: Regulate serotonin levels, reduce anxiety, and help stabilize nervous system overactivity.

• Side Effects: Nausea, insomnia, weight gain, and (rarely) serotonin syndrome.

13. Erythropoietin (Procrit®)

Boosts red blood cell production to enhance circulation and oxygen transport.

• Benefits: Supports patients with anemia or severe fatigue; may stabilize blood pressure.

• Side Effects: Increased blood pressure, higher risk of blood clots.

14. Yohimbine

An herbal alkaloid sometimes used for blood pressure regulation.

• Benefits: Improves circulation and can help patients with neurogenic orthostatic hypotension.

• Side Effects: Anxiety, insomnia, rapid heartbeat.

15. Ivabradine (Corlanor®)

Lowers heart rate without lowering blood pressure.

• Benefits: Often prescribed for POTS and inappropriate sinus tachycardia (IST); helps reduce palpitations and fatigue.

• Side Effects: Visual disturbances, dizziness, bradycardia.

16. Somatostatin (Octreotide®)

Influences blood vessel constriction to help regulate blood pressure.

• Benefits: Used in autonomic failure and postural hypotension.

• Side Effects: Abdominal pain, nausea, gallstones.

17. Desmopressin (DDAVP®)

Impacts fluid retention, helping stabilize blood volume.

• Benefits: Improves low blood volume in POTS and orthostatic hypotension; reduces dehydration risk.

• Side Effects: Headaches, nausea, low sodium (hyponatremia).

18. Bethanechol (Urecholine®)

Stimulates nerve signaling to improve digestive and urinary function.

• Benefits: Can help with bladder dysfunction and digestive motility issues.

• Side Effects: Sweating, cramps, low heart rate.

19. H1 & H2 Antihistamines

Commonly used for mast cell regulation in Dysautonomia patients.

• Benefits: Reduces dizziness, flushing, and MCAS-related symptoms.

• Side Effects: Brain fog, drowsiness, dry mouth.

20. Acetylcholinesterase Inhibitors (e.g., Donepezil)

Enhance nerve signaling to strengthen autonomic regulation.

• Benefits: Improves cognition, focus, and nervous system responses.

• Side Effects: Sweating, nausea, muscle cramps.

Medications vs. Root Cause Healing: What’s Missing?

While medications may relieve symptoms, they do not address what’s actually fueling Dysautonomia. Some common root causes include:

• Chronic infections (Lyme, Epstein-Barr, mold toxicity)

• Hormonal imbalances (adrenal fatigue, estrogen dominance)

• Nutrient deficiencies (B12, magnesium, sodium imbalances)

• Nervous system dysregulation (high cortisol, vagus nerve dysfunction)

If these drivers aren’t addressed, symptom management often turns into a lifelong cycle of chasing relief rather than achieving true recovery.

This is where holistic strategies come in supporting the body’s natural healing pathways and addressing underlying imbalances. For example, Wellhistic’s Hormone & PMS Support is designed to bring balance to monthly cycles, while CALM helps regulate stress and nervous system overactivity, two factors that often worsen Dysautonomia symptoms.

What’s Next: Holistic Healing Approaches

Now that we’ve completed the overview of 20 Dysautonomia medications, it’s time to explore natural therapies that target healing from the inside out. These strategies focus on restoring balance, calming the nervous system, and strengthening resilience rather than just suppressing symptoms.

📌 Stay tuned for Part 4: Holistic Dysautonomia Treatments – Addressing the Root Cause.

Take the Next Step

• Try our Dysautonomia Symptom Quiz to discover your unique triggers.

• Join our Wellhistic Support Community for ongoing resources and guidance.

• Explore our next blog on Holistic Dysautonomia Treatments for root-cause healing.

💙 At Wellhistic, our mission is to empower you with knowledge, whether you choose medications, holistic support, or a blend of both. Healing isn’t one-size-fits-all—but you deserve options that work for you.